John Barrymore

Don Jose de Marana / Don Juan de Marana

Jane Winton

Donna Isobel

John Roche

Leandro

Warner Oland

Cesare Borgia

Estelle Taylor

Lucrezia Borgia

Montagu Love

Count Giano Donati

Josef Swickard

Duke Della Varnese

Willard Louis

Pedrillo

Nigel De Brulier

Marchese Rinaldo

Hedda Hopper

Marchesia Rinaldo

Myrna Loy

Mai - Lady in Waiting

Mary Astor

Adriana della Varnese

Lionel Braham

Duke Margoni (uncredited)

Helene Costello

Rena - Adriana's Maid (uncredited)

Helena D'Algy

Donna Elvira (uncredited)

Jacob Dance

Gentleman (uncredited)

Yvonne Day

Don Juan - at age 5 (uncredited)

Philippe De Lacy

Don Juan - at age 10 (uncredited)

Emily Fitzroy

The Dowager (uncredited)

John George

Hunchback (uncredited)

Gibson Gowland

Gentleman of Rome (uncredited)

Phyllis Haver

Imperia (uncredited)

Sheldon Lewis

Gentleman of Rome (uncredited)

June Marlowe

Trusia (uncredited)

Dick Sutherland

Gentleman of Rome (uncredited)

Gustav von Seyffertitz

Neri - the Alchemist (uncredited)

Helen Lee Worthing

Eleanora (uncredited)