Frank Welker

Scooby-Doo / Fred Jones / Msicellaneous Bikers (voice)

Mindy Cohn

Velma Dinkley (voice)

Grey DeLisle-Griffin

Daphne Blake (voice)

Matthew Lillard

Shaggy Rogers / Shaky Joe (voice)

Cathy Cavadini

Faith (voice)

John DiMaggio

Friz / GPS / Msicellaneous Bikers (voice)

Michael Gough

Mr. Babbit / Blair / Grad Student #1 / Bikers (voice)

Matthew Gray Gubler

Winsor (voice)

Finola Hughes

Professor Svankmajer (voice)

Maulik Pancholy

Doctor (voice)

Kevin Michael Richardson

Tex / Cop #2 / Grad Student #3 / Bikers (voice)

Fred Willard

Mr. Hubley (voice)

Dave Wittenberg

Policeman / Cop #1 / Grad Student #2 / Bikers (voice)

Gwendoline Yeo

Ms. Deitch (voice)