Oprah Winfrey

Deborah Lacks

Rose Byrne

Rebecca Skloot

Renée Elise Goldsberry

Henrietta Lacks

Reg E. Cathey

Zakariyyah

Courtney B. Vance

Sir Lord Keenan Coefield

Rocky Carroll

Sonny Lacks

Leslie Uggams

Sadie

Reed Birney

Dr. George Gey

John Douglas Thompson

Lawrence Lacks

Adriane Lenox

Barbara Lacks

Roger Robinson

Day Lacks

John Beasley

Cliff

Peter Gerety

Paul Lurz

Gabriel Ebert

Christoph Lengauer

John Benjamin Hickey

Bill Watson

Ruben Santiago-Hudson

Dr. Roland Pattillo

Byron Jennings

Dr. Victor McKusick

Sylvia Grace Crim

Mary Kubicek

Karen Wheeling Reynolds

Mrs. Gey

John C. Vennema

Board Administrator

Jaedon Godley

Davon Lacks

Kyanna Simone Simpson

Deborah (15-24YRS)

Jane Rumbaua

Dr. Susan Hsu

Jaylon Gordon

Alfred

Leon Lamar

Cootie

Andrea Frye

Gladys

Jazzy Ellis

Young Gladys

Tinashe Kajese

Sadie

Patrick Walker

Cousin Fred

L. Warren Young

Day Lacks

Ellen Barkin

Sasha Walz

Michael Gaston

Richard Wilson

Kate Bond

Young Woman

Tyvonna Jones

Elsie Lacks

Bill Martin Williams

Crownsville Administrator

Mary Shaw

Woman at Pump

Tian Richards

Lawrence (16 yrs.)

Kermit Burns III

Young Cootie

Lisa Arrindell

Aunt Ethel

Jordan Eli Arellano

Young Sonny Lacks

Kayla Anderson

Johns Hopkins Student

De'Marco Arrington

Young Joe

Matthew Bernard

Johns Hopkins Student

Raphael Dante' Carr Jr.

Young Sonny

Ninja N. Devoe

Country Girl Mae

Clint Edwards

Scientist

Christopher Robert Escobar

Chris the Intern

Sean Freeland

Charlie

Elizabeth Hackler

Rebecca's Co-worker

Linden Harris

Galen (as Linden Ronel Harris)

Todd Lee

Doctor

Miguel Angel Marrero

Scientist

Sage Mayer

Young Boy

Jock McKissic

Carl the Mechanic

Tatom Pender

Johns Hopkins Nurse

Earl Poitier

Cousin Josh

David Shae

Reporter

Tashaun Stanfill-Perry

Henrietta Lacks Neighbor

Alpha Trivette

First Administrator

Terrence V. Walker

Church Patron