George Clinton

Host

Robert Guillaume

Gleason Golightly (segment 'Space Traders')

Michele Lamar Richards

Gail Golightly (segment 'Space Traders')

Jason Bernard

Bernard Shields (segment 'Space Traders')

Edward Edwards

Chief of Staff (segment 'Space Traders')

George Wallace

Piggy (segment 'Space Traders')

Brian Reddy

Vice President (segment 'Space Traders')

Larry Anderson

Stryker O'Rourke (segment 'Space Traders')

Brock Peters

Minister Coombs (segment 'Space Traders')

Bob Gunton

President Ellis (segment 'Space Traders')

Nicholas Turturro

Father Carlos (segment 'The First Commandment')

Efrain Figueroa

Padrino (segment 'The First Commandment')

Richard Herd

Cardinal (segment 'The First Commandment')

Paula Jai Parker

Tang (segment 'Tang')

Chi McBride

T-Bone (segment 'Tang')

Bertice Berry

(segment 'Space Traders')

Franklin Cover

(segment 'Space Traders')

Casey Kasem

(segment 'Space Traders')

Roxie Roker

(segment 'Space Traders')

Ebonie Smith

Jennifer (segment 'Space Traders')

Craig Kirkwood

Lenny (segment 'Space Traders')

Liz Larou

Ute (segment 'Space Traders')

Jaye Koch

Alien Press Secretary (segment 'Space Traders')

Marte Boyle Slout

Helen Hipmeyer (segment 'Space Traders')

Joseph G. Medalis

Defense Secretary (segment 'Space Traders')

James Noah

Interior Secretary (segment 'Space Traders')

Tom Finnegan

General Wright (segment 'Space Traders')

Arthur Burghardt

Justin Jasper (segment 'Space Traders')

Roger Guenveur Smith

Dr. Erik Fanon (segment 'Space Traders')

Roger Marks

Rabbi Spector (segment 'Space Traders')

Lamont Johnson

Civil Rights Leader (segment 'Space Traders')

Jedda Jones

Woman in Audience (segment 'Space Traders')

Robert Covarrubias

Hispanic Leader (segment 'Space Traders')

Cynthia Madvig

Cigarette Girl (segment 'Space Traders')

Jim Jansen

Liquor Company CEO (segment 'Space Traders')

Dennis Howard

Petroleum Co. CEO #1 (segment 'Space Traders')

Paul Kent

Petroleum Co. CEO #2 (segment 'Space Traders')

Steve Stapenhorst

Home Products CEO (segment 'Space Traders')

Ann Walker

Audience Member #1 (segment 'Space Traders')

Myra J.

Audience Member #2 (segment 'Space Traders')

J. Kenneth Campbell

Mr. Spivey (segment 'The First Commandment')

Daryl Mitchell

Mover #1 (segment 'The First Commandment')

Eugene Allen

Mover #2 (segment 'The First Commandment')

Noëlle Balfour

The Saint (segment 'The First Commandment')

Robert Wisdom

Captain Jackson (segment 'The First Commandment')

Marcus Salgado

Young Man in the Botanica (segment 'The First Commandment')

George Logan

Male Drug Dealer (segment 'The First Commandment')

Kelly Jo Minter

Female Drug Dealer (segment 'The First Commandment')

Ana Mercedes

Blessed Woman (segment 'The First Commandment')

John Witherspoon

Homeless Man #1 (segment 'The First Commandment')

Chino 'Fats' Williams

Homeless Man #2 (segment 'The First Commandment')

Bowlegged Lou

Homeless Man #3 (segment 'The First Commandment')

Peter Vogt

T.V. Reporter (segment 'The First Commandment')

Roma Alvarez

Old Lady at Church (segment 'The First Commandment')

Paul Anthony

Crack House Thug #1 (segment 'The First Commandment')

B-Fine

Crack House Thug #2 (segment 'The First Commandment')

Tony Canty

Santeria Practitioner (segment 'The First Commandment')

Janus Brown

Santeria Practitioner (segment 'The First Commandment')

Bobby Mateos

Santeria Practitioner (segment 'The First Commandment')

Joey DeLeon

Santeria Practitioner (segment 'The First Commandment')

Robert Melendez

Santeria Practitioner (segment 'The First Commandment')

Margaux Dinerman

Santeria Practitioner (segment 'The First Commandment')

Noah Nichel

Santeria Practitioner (segment 'The First Commandment')

Felicidad Gongora

Santeria Practitioner (segment 'The First Commandment')

Henry Williams

Santeria Practitioner (segment 'The First Commandment')

Irma Williams

Oshun (segment 'The First Commandment')

Reno Wilson

The Messenger (segment 'Tang')

Tom Williams

Education Secretary (segment "Space Raiders")