Dan Aykroyd

Vic's Buddy

Candice Bergen

Murphy Brown

James Brolin

Doctor

Downtown Julie Brown

Self

Jeff Bergman

Bugs Bunny / Porky Pig / Tweety (voice)

Chevy Chase

Vic's Buddy

Kevin Costner

Bartender

Rodney Dangerfield

Vinny Boombatz

Geena Davis

Kim

Dana Delany

Doctor

Danny DeVito

Vic

Michael Douglas

Self

Jane Fonda

Hellen

Morgan Freeman

Walter Samson

Will Smith

Fresh Prince

Neil Patrick Harris

Doogie Howser

Heavy D

Self

Dustin Hoffman

Every Lawyer

Ice-T

Self

Magic Johnson

Self

Quincy Jones

Self

Michael Keaton

Charles McIntyre

Christopher Reid

Kid

Christopher Martin

Play

Christopher Lloyd

Emmett Brown

Jack Lemmon

Coach Stewart

Melanie Mayron

Self

Bette Midler

Mother Earth

Dennis Miller

Weekend Update Anchor

Rick Moranis

Vic's Buddy

Jim Henson

Kermit the Frog (voice)

Jerry Nelson

Robin the Frog (voice)

Dave Goelz

Old Frog (voice)

Richard Hunt

Crocodile (voice)

David Rudman

Lizard (voice)

Kevin Clash

Muppets (voice)

Steve Whitmire

Muppets (voice)

Edward James Olmos

Hospital Director

Rhea Perlman

Paula

Queen Latifah

Self

Harold Ramis

Elon Spengler

Pat Riley

Self

Carl Sagan

Self

Martin Short

Nathan Thurm

Meryl Streep

Concerned Citizen

Barbra Streisand

Self

Tone Loc

Self

Robin Williams

Everyman

Kirstie Alley

Rebecca Howe

Ted Danson

Sam Malone

Kelsey Grammer

Dr. Frasier Crane

Woody Harrelson

Woody Boyd

John Ratzenberger

Cliff Clavin

George Wendt

Norm Peterson

Tempestt Bledsoe

Vanessa Huxtable

Lisa Bonet

Denise Huxtable

Bill Cosby

Cliff Huxtable

Keshia Knight Pulliam

Rudy Huxtable

Phylicia Rashād

Clair Huxtable

Raven-Symoné

Olivia Kendall

Malcolm-Jamal Warner

Theo Huxtable

Jim Lange

Self

Bea Arthur

Dorothy Zbornak

Estelle Getty

Sophia Petrillo

Rue McClanahan

Blanche Devereaux

Betty White

Rose Nylund

Alex Trebek

Self

Christina Applegate

Kelly Bundy

Amanda Bearse

Marcy D'Arcy

David Faustino

Bud Bundy

Ed O'Neill

Al Bundy

Katey Sagal

Peggy Bundy

Mayim Bialik

Self

Jonathan Brandis

Self

Rick Ducommun

Guard

Dan Gauthier

Self

Edan Gross

Self

Dom Irrera

Self

Robert Wuhl

Self

Rickey Boyd

Self (uncredited)

Danny 'Budman' Delany

Self (uncredited)

Michael Gio Ferrigno

Self (uncredited)

Peter Horton

Self (uncredited)

Bruce Weitz

Self (uncredited)

Don Pardo

Weekend Update Announcer (voice) (uncredited)