Dudley Moore

Dr. Jack Hammond / Chris Hammond

Kirk Cameron

Chris Hammond / Dr. Jack Hammond

Margaret Colin

Ginnie Armbruster

Catherine Hicks

Dr. Amy Larkin

Patrick O'Neal

Dr. Larry Armbruster

Sean Astin

Clarence / Trigger

Camille Cooper

Lori Beaumont

Micah Grant

Rick Anderson, Lori's Boyfriend

Bill Morrison

Trigger's Uncle Earl

Skeeter Vaughan

Medicine Man

Larry Sellers

Navajo Helper

Tami David

Navajo Girl

Maxine Stuart

Phyllis, Hammonds' Housekeeper

David Wohl

Dr. Roger Hartwood

Michael Horton

Dr. Mike O'Donald

Randy Lowell

Dr. Spellner

Art Frankel

Mr. Racine, Heart Patient

Christine Healy

Hospital Administrator

Mary Jane Courier

Operating Nurse

Debbie Zipp

Nurse with Dying Patient

Teresa Bowman

Nurse with Heart Patient

Brian Peck

Intern with Heart Patient

Carol Swarbrick

Norma, Hospital Secretary

Kedric Wolfe

Sidney, Board Member

Robert Balderson

Hal Gilden, Board Member

Dakin Matthews

Old Man Morrison

Les Lannom

Coach Ellis

Lorna Hill

Mrs. Davis

John Stinson

Math Teacher

Bill Stevenson

Biology Student

Alexandra Kenworthy

Janice Stenfield, College Interviewer

Jamison Selby

Rick's Friend

Lloyd Nelson

Teacher in Hall

John Tokatlian

Student

Mark McCannon

Student

Jan Duncan

Student

Armin Shimerman

Trigger's Dad

Kitty Swink

Trigger's Mom

Lisa Robins

Bartender

James Lashly

Freemont, Corky's Man

Corki Grazer

Corky, Woman in Labor

Nancy Lenehan

Waitress in Desert Diner

Richard Gonzales

Paper Boy (as Richard Gilberts)