Grey DeLisle

Mandy (voice)

Ben Diskin

Numbuh 1 / Numbuh 2 / Delightful Children F.D.T.L. (voice)

Lauren Tom

Numbuh 3 (voice)

Dee Bradley Baker

Numbuh 4 / Delightful Children F.D.T.L. (voice)

Cree Summer

Numbuh 5 / Delightful Children F.D.T.L. (voice)

Richard Steven Horvitz

Billy / Harold (voice)

Greg Eagles

Grim (voice)

Rachael MacFarlane

Numbuh 362 (voice)

Matt Levin

Numbuh 60 (voice)

Tony Sampson

Eddy (voice)

C.H. Greenblatt

Fred Fredburger (voice)

Rachael MacFarlane

Mindy / Numbuh 362 (voice)

Vanessa Marshall

Irwin (voice)

Dave Wittenberg

Numbuh 74.239 (voice)

Matt Hill

Ed (voice) (uncredited)

Sam Vincent

Edd (voice) (uncredited)