Debi Derryberry

Jimmy Neutron / Alien Actress / Alien Woman (voice)

Rob Paulsen

Carl Wheezer/Mr. Wheezer/Mrs. Wheezer/Test Pilot/Announcer (voice)

Jeffrey Garcia

Sheen Estevez / Army Guard (voice)

Frank Welker

Goddard (voice)

Carolyn Lawrence

Cindy Vortex (voice)

Crystal Scales

Libby Folfax (voice)

Tim Allen

Meldar Prime (voice)

Alyssa Milano

April (voice)

Carlos Alazraqui

Sr. Estevez (voice)

Jeff Bennett

Gorlock #2 / Brain #1 (voice)

Megan Cavanagh

Judy Neutron / Mrs. Vortex (voice)

Jim Cummings

Brain #2 / Mayor Quadar (voice)

Mark DeCarlo

Hugh Neutron / Emergency System / Gen. Abercrombie (voice)

Jess Harnell

Meldar Prime (singing voice)

Joe Lala

Sr. Estevez (voice)

Phil LaMarr

Bolbi Stroganofsky / British Tourist (voice)

Billy West

Sam / Corky Shumatsu (voice)

Grey DeLisle-Griffin

Vendanna (voice)