Sarah Silverman

Self

Nathan Barnatt

Homeless Man (segment "Lisa")

Lauren Lapkus

Girl 5 (segment "Lisa")

John C. Reilly

Father (segment "Ham")

Laura Silverman

Self (segment "Knickers")

Seth Rogen

Officer Durand (segment "Knickers")

Jade Catta-Preta

Mother (segment "Lisa")

Natasha Leggero

Girl 2 (segment "Lisa")

Shelby Fero

Girl 1 (segment "Lisa")

Nathan Fielder

Self (segment "Retro Video Arcade")

David Dineen-Porter

Self (segment "Retro Video Arcade")

Kyle Dunnigan

Self

Michael Daniel Cassady

Self (segment "Lisa")

Brett Gelman

Self

Emily Maya Mills

Girl 6 (segment "Lisa")

Nick Rutherford

Father (segment "Lisa")

Rob Schrab

Self

Paul Rust

Self (segment "Lisa")

Stoney Sharp

Self

Armen Weitzman

Mailman

Kulap Vilaysack

Girl 3 (segment "Lisa")

Eric Wareheim

Self

Harris Wittels

Scientist 1 (segment "CCDF")

Charlyne Yi

Self

Tig Notaro

Girl 4 (segment "Lisa")

Todd Glass

Self

Grace Helbig

Bride 5 (segment "Absorption")

2 Chainz

Self (segment "Absorption")

Casey Ford Alexander

Bad Guy 2 (segment "CCDF")

Jack Bornoff

Tomato Man (segment "Ham")

Hailey Boyle

Cashier (segment "Knickers")

Aaron Chrenen

Cooper (segment "Ginger Orphan Playhouse") (voice)

Larry A. Davies

Lloyd (segment "Absorption")

Greg Davis Jr.

Groom 2 (segment "Absorption")

Donna DuBain

Madame Trinkett (segment "Ginger Orphan Playhouse") (voice)

Trevor Eyster

Bad Guy 1 (segment "CCDF")

Malinda Farrington

Malinda (segment "Ham")

Kate Freund

Prostitute (segment "CCDF")

David Garcia

Bad Guy 3 (segment "CCDF")

Cyrus Ghahremani

Self

Hannah Hart

Bride 4 (segment "Absorption")

Deloris Heard

Customer (segment "Knickers")

Pamela Immel

Pamela (segment "Ham")

Zack Kennedy

Band Member 4 (segment "Absorption")

Keegan-Michael Key

Self (segment "Absorption")

Ben Lepley

Vacuum Salesman (segment "Ginger Orphan Playhouse") (voice)

Catherine Lydon

Cashier (segment "Ham")

Rasika Mathur

Bride 3 (segment "Absorption")

Kyle Pacek

Son (segment "Ham")

Sandeep Parikh

Groom 3 (segment "Absorption")

Jordan Peele

Self (segment "Absorption")

Issa Rae

Bride 2 (segment "Absorption")

Ron Ransen

Band Member 1 (segment "Absorption")

Mike Relm

Self

Willy Roberts

Taco Truck Worker (segment "CCDF")

Chase Stewart

Son (segment "Lisa")

Mark Taormino

Band Member 2 (segment "Absorption")

Brittani Taylor

Bride 1 (segment "Absorption")

Aono Tetsuji

Bad Guy 4 (segment "CCDF")

James Trenton

James (segment "Ham")

Jack Vale

Groom 1 (segment "Absorption")