Buster Jones

James 'Twiggy' Sanders / Spaghetti Man (voice)

Scatman Crothers

Nate Branch / Liquid Man (voice)

Adam Wade

Louis 'Sweet Lou' Dunbar / Gizmo (voice)

Johnny Williams

Hubert 'Geese' Ausbie / Multi Man (voice)

Stu Gilliam

Freddie 'Curly' Neal / Super Sphere (voice)

Frank Welker

Crime Globe (voice)

Michael Rye

Narrator (voice)