Julia Duffy

Charlotte (voice)

David Berón

Wilbur

Charlie Adler

Templeton / Lurvy (voice)

Amanda Bynes

Nellie

Maria Bamford

Aranea (voice)

Debi Derryberry

Fern

Laraine Newman

Gwen (voice)

Anndi McAfee

Joy (voice)

Harrison Chad

Cardigan

Rob Paulsen

Farley

Dawnn Lewis

Bessie

Brenda Vaccaro

Mrs. Hirsch

Jerry Houser

Mr. Zuckerman

Valery Pappas

High Strung Chicken

Nika Futterman

Baby Rats