Margarita Fischer

Eliza

James B. Lowe

Uncle Tom

Arthur Edmund Carewe

George Harris

George Siegmann

Simon Legree

Eulalie Jensen

Cassy

Mona Ray

Topsy

Virginia Grey

Evangeline 'Eva' St. Clare

Lassie Lou Ahern

Little Harry

Lucien Littlefield

Lawyer Marks

Adolph Milar

Mr. Haley

J. Gordon Russell

Loker

Gertrude Howard

Aunt Chloe

Jack Mower

Mr. Shelby

Vivien Oakland

Mrs. Shelby

John Roche

Augustine St. Claire

Aileen Manning

Aunt Ophelia

Gertrude Astor

Mrs. St. Clare (uncredited)

Francis Ford

Captain (uncredited)

Rolfe Sedan

Adolph (uncredited)

Dick Sutherland

Sambo (uncredited)

Nelson McDowell

Phineas Fletcher (uncredited)

Rondo Hatton

Slave (uncredited)

C.E. Anderson

Johnson (uncredited)

Carla Laemmle

Auction Spectator (uncredited)

Jeanette Loff

Auction Spectator (uncredited)

Madame Sul-Te-Wan

Slave at Wedding (uncredited)

Clarence Wilson

Bidder at Eliza's Auction (uncredited)