Reeve Carney

Peter Parker/Spider-Man

Jennifer Damiano

Mary Jane Watson

T.V. Carpio

Arachne

Patrick Page

Norman Osborn/Green Goblin

Matthew James Thomas

Peter Parker/Spider-Man [at certain performances]

Michael Mulheren

J. Jonah Jameson

Ken Marks

Buttons/ Ensemble/ Uncle Ben/ Viper Executive

Isabel Keating

Aunt May/ Maxie/ Mrs. Gribrock

Jeb Brown

Ensemble/ MJ's Father/ Stokes/ Viper Executive

Laura Beth Wells

Emily Osborn/ Ensemble/ Marbles

Matt Caplan

Bud/ Ensemble/ Flash/ Gangster

Dwayne Clark

Boyle/ Ensemble/ Gangster/ Robertson/ Viper Executive

Luther Creek

Ensemble/ Gangster/ Kong/ Travis/ Viper Executive

Gerald Avery

Ensemble/ Swarm

Collin Baja

Carnage/ Ensemble/ Green Goblin Flyer

Marcus Bellamy

Ensemble

Emmanuel Brown

Electro/ Ensemble

Craig Henningsen

Ensemble/ Exterminator Flyer

Dana Marie Ingraham

Ensemble

Ayo Jackson

Ensemble

Natalie Lomonte

Ensemble

Kristen Martin

Ensemble

Jodi McFadden

Ensemble

Bethan Moore

Ensemble

Kristen Faith Oei

Ensemble

Jennifer Christine Perry

Ensemble

Brandon Rubendall

Ensemble/ The Lizard

Sean Samuels

Ensemble/ Purse Snatcher/ Swiss Miss

Dollar Tan

Ensemble

Christopher W. Tierney

Ensemble/ Hero Flyer/ Kraven the Hunter/ Meeks