Steve Whitmire

Kermit the Frog / Rizzo the Rat / Beaker / Elvises (voice)

Dave Goelz

The Great Gonzo / Dr. Bunsen Honeydew / Waldorf / Zoot (voice)

Bill Barretta

Pepe the King Prawn / Bobo the Bear / Johnny Fiama / Swedish Chef / Lew Zealand / Howard Tubman / Rowlf the Dog / Elvises (voice)

Eric Jacobson

Miss Piggy / Fozzie Bear / Animal / Yoda / Elvises (voice)

David Arquette

Daniel

Joan Cusack

Rachel Bitterman

Matthew Lillard

Luc Fromage

William H. Macy

Glenn

Whoopi Goldberg

Daniel's 'Boss'

Carson Daly

Self

Kelly Ripa

Self

Joe Rogan

Self

Molly Shannon

Self

Robert Smigel

Triumph, the Insult Comic Dog (voice)

Zach Braff

Dr. John "J.D." Dorian

Sarah Chalke

Dr. Elliot Reid

Neil Flynn

Janitor

John C. McGinley

Dr. Perry Cox

Judy Reyes

Nurse Carla Espinosa

Bill Lawrence

Self

Mel Brooks

Joe Snow (voice)

Dave 'Squatch' Ward

Sally Ann Santa Claus

Brian Henson

Scooter / Janice / Sal Minella (voice)

Kevin Clash

Sam Eagle (voice)

John Henson

Sweetums (voice)

Jerry Nelson

Robin the Frog / Statler / Announcer / Pops / Floyd Pepper

John E. Kennedy

Dr. Teeth (voice)

Allan Trautman

Eugene the Tuba Player (voice)

Alice Dinnean

Additional Muppet Performer (voice)

Geoff Redknap

Additional Muppet Performer (voice)/ Sweetums

Denise Cheshire

Additional Muppet Performer (voice)

Drew Massey

Additional Muppet Performer (voice)

Adam Behr

Additional Muppet Performer (voice)

Gord Robertson

Additional Muppet Performer (voice)

Dawn Lewis

Fear Factor Contestant

Colin Foo

Security Guard

Marci Dacus

Fear Factor Contestant (uncredited)

Yee Jee Tso

Angel 1

Dan Joffre

Angel 2

Jonathan Bruce

Fat Angel

Cameron McDonald

Safari Animal Tracker

Darrell Lee-Izeard

Thin Angel

Chantal Strand

Nancy Nut-What

Robin Mossley

Nicki Nut-What

Dan Payne

Handsome Executive

Julia Arkos

Sally Ann Representative