Tracey Ullman

Louise "Little Lulu" Moppet (voice)

Bruce Dinsmore

Thomas "Tubby" Tompkins (voice)

Vanessa Lengies

Annie Inch (voice)

Dawn Ford

Iggy Inch (voice)

Justin Bradley

Eddie Stimson (voice)

Jacob Tierney

Wilbur Van Snobbe (voice)

Ricky Mabe

Willie Wilkins

Angelina Boivin

Gloria Goode Darling / Margie (voice)

Jonathan Koensgen

Alvin Jones

Pauline Little

Mrs. Martha Moppet (voice)

Gary Jewell

Mr. George Moppet

Susan Glover

Mrs. Ellie Tompkins (voice)

Terrence Scammell

Mr. Jim Tompkins / Officer McNabb (voice)

Michael Yarmush

Butch, the Lead West Side Boy (voice)